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  • Verified research peptides · Cyprus
Metabolism 6 min read2026-07-06

Retatrutide (GLP-III): a research overview

What the research literature says about retatrutide as a triple-agonist reference peptide — classification, targets, and how it is studied in vitro.

By Peptide Cyprus

Key takeaways

  • Retatrutide (GLP-III / Triple G) is a synthetic triple-agonist reference peptide.
  • It is studied in vitro at three receptor targets: GLP-1, GIP and glucagon.
  • CAS 2381089-83-2 · MW 4731.3 g/mol · verified per batch by HPLC and LC-MS.
  • Supplied strictly as a reference material for in-vitro laboratory research.

What retatrutide is

Retatrutide — also written GLP-III or "Triple G" — is a synthetic peptide that has become one of the most-searched compounds in metabolic research. It is supplied as a lyophilized reference standard for in-vitro laboratory study only; Peptide Cyprus makes no human-use or efficacy claims.

Why "triple" agonist

In published in-vitro research, retatrutide is described as a single molecule that engages three receptor targets — GLP-1, GIP and glucagon. This triple-agonism is precisely what makes it a subject of metabolic-signalling and energy-balance research models.

Molecular data

Retatrutide carries CAS 2381089-83-2, a molecular weight of 4731.3 g/mol and formula C221H342N46O68. As a reference material it is characterised by this data and verified per batch by HPLC and LC-MS.

Handling in the lab

Store lyophilized at −20 °C, protected from light. Reconstitute with bacteriostatic water for laboratory measurement, then keep refrigerated at 2–8 °C. The reconstitution calculator gives concentration and draw volumes.

Frequently asked

Yes — Peptide Cyprus stocks retatrutide as a ≥99% HPLC-verified reference standard with independent batch analyses, shipped across Cyprus and the EU for laboratory research.

Research use only. This reference material is for in-vitro laboratory research. Not for human or animal consumption.

Verified reference materials

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Retatrutide

GLP-III · Triple G

10 mg20 mg

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